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A lead representative of Series 1 (KLS-116) shows the distinct architecture of MetalloBio’s proprietary inorganic chemistry platform.
Two highly thermostable ruthenium-nitrogen complexes provide a substrate for the addition of ligands at four positions around the core bridged structure. Each of the 4 ligands can be varied providing a vast range of analogue possibilities which affect the properties of the compounds.
Target Indications
The company is building a preclinical data package to support a primary complicated bacterial infection indication. There are several such indications and ongoing work is focused on evaluating compounds so as to assess the best fit between pharmacological profile and the specific requirements of treating any given complicated bacterial infection.
